Results. Pharmacokinetic parameters for ibuprofen and paracetamol were similar for the combination and monotherapy tablets (values falling within the 80% to 125% acceptable bioequivalence range) except for the rate of absorption of paracetamol from the combination (t max), which was significantly faster compared with monotherapy (median difference 10 minutes; p < 0.05).. Descriptions. Ibuprofen and acetaminophen combination is used to relieve minor aches and pains including headache, backache, toothache, menstrual cramps, muscle aches, or arthritis pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain.
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The use of the fixed-dose combination may represent advantage in terms of efficacy and safety, allowing a better control of the dose of both paracetamol and ibuprofen as monotherapy, thus minimizing the risk of incorrect dosage. However, the limited evidence available highlights the need for future.. The mean time without fever was 36 ± 8.60 hours for paracetamol, 38.72 ± 9.12 hours for ibuprofen, and 42.82 ± 3.54 hours for paracetamol and ibuprofen combination. On statistical analysis, we observed that the paracetamol and ibuprofen combination is clearly superior to paracetamol alone (p < 0.001) as well as to ibuprofen alone (p = 0.014).
